United States
Hong KongSchedule II rules
Refilling a Schedule II prescription is prohibited outright at 21 CFR 1306.12. Schedule I and II ordering requires DEA Form 222 or its electronic equivalent under 21 CFR Part 1305.
If you learn one block of federal rules precisely, make it this one. It generates more questions than any other single point in the domain.
No refills
The refilling of a prescription for a controlled substance listed in Schedule II is prohibited. That is 21 CFR 1306.12, and it is unconditional.
Refills written on a Schedule II prescription do not create an authority to dispense them. The exam tests this by presenting a prescription with refills expressly authorized, which reads as permission and is not. The original fill is all that may be dispensed.
Ordering
Schedules I and II are ordered on DEA Form 222 or through the electronic equivalent, under 21 CFR Part 1305. Schedules III to V are not. Two numbers, two purposes.
That distinction is a common question because it is one of the few places where the paperwork differs visibly by schedule.
Recordkeeping
Records and inventories must be kept for at least two years, under 21 CFR 1304.04. A biennial inventory may be taken on any date within two years of the previous one, under 21 CFR 1304.11. Learn it as a sentence.
Note that biennial means every two years, not twice a year. It is a routinely mistaken word and the regulation is explicit about the interval.
Loss and theft
Theft or significant loss of controlled substances is reported to DEA on Form 106.
Form 222 orders, Form 106 reports a loss. Two numbers, two purposes, and swapping them is the classic distractor.
What the questions look like
A fact pattern with a plausible-sounding permission in it, and four options of which one is the rule and three are the things people believe.
The defense is knowing the rule as a sentence rather than as a general impression of strictness.
Common questions
Can a Schedule II prescription be refilled?
No. Refilling is prohibited at 21 CFR 1306.12, regardless of what the prescriber wrote.
What form orders Schedule II drugs?
DEA Form 222 or its electronic equivalent, under 21 CFR Part 1305.
How long are records kept?
At least two years, under 21 CFR 1304.04.
What does biennial inventory mean?
Every two years, not twice a year. 21 CFR 1304.11.
Which form reports a theft?
DEA Form 106. Form 222 orders; Form 106 reports a loss.