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Sig codes

Compiled by the Sitonce editorial team from PTCB's own published outline, the federal regulations named below and US Bureau of Labor Statistics dataUpdated 2 min readFacts verified 5 September 2026
The short answer

Sig codes encode route, frequency and timing. The exam tests the ones that resemble each other, so learning them in contrasting pairs beats learning a list.

Pure recall, and worth securing early because every days-supply question depends on it.

Frequency

CodeMeansDoses a day
QD or dailyOnce a day1
BIDTwice a day2
TIDThree times a day3
QIDFour times a day4
Q4HEvery four hours6
Q6HEvery six hours4
Q8HEvery eight hours3
Q12HEvery twelve hours2
PRNAs neededVariable
PRN breaks days supply questions

An as-needed instruction has no fixed daily quantity, so days supply cannot be calculated from the Sig alone. Where a question involves PRN it will give you a maximum daily use, and that maximum is what you calculate with.

Route

CodeMeans
POBy mouth
SLSublingual
PRRectally
IVIntravenous
IMIntramuscular
SC or SubQSubcutaneous
OD, OS, OURight eye, left eye, both eyes
AD, AS, AURight ear, left ear, both ears

The pairs that catch people

The eye and ear codes are the classic. O is for eye and A is for ear, D is right and S is left, U is both. Getting the letter families the wrong way round is a recognized error type, which is why the plain-English forms are now preferred in practice.

Q6H and QID both mean four a day but they are not interchangeable in scheduling, and the exam sometimes cares about the difference.

Quantity and timing

  • AC before meals, PC after meals
  • HS at bedtime
  • STAT immediately
  • gtt drop, tsp teaspoon, tbsp tablespoon
  • ss one half

How to learn them

In contrasting pairs rather than alphabetically. AC against PC, OD against AD, Q6H against QID. The exam tests the confusion, so practice the confusion.

Common questions

What does BID mean?

Twice a day. TID is three times and QID is four.

How many doses is Q4H?

Six a day.

What do OD and AD mean?

OD is right eye and AD is right ear. O is eye, A is ear, D is right, S is left, U is both.

Why is PRN a problem for days supply?

It has no fixed daily quantity, so the question must supply a maximum daily use.

How should I learn Sig codes?

In contrasting pairs, because the exam tests the ones that look alike.